Auchenflower is located 2.5 kilometres west of the Brisbane CBD bordering the Brisbane River. The area was formerly populated by rural estates, one of which was named Auchenflower by Thomas McIlwraith circa 1880. The name Auchenflower is a Gaelic word meaning field of flowers.
Between 1900 and 1962 Auchenflower was served by trams running along Milton Road from Toowong. The services were withdrawn after the disastrous Paddington tram depot fire.
From 1975 to 1986, Auchenflower was officially a neighbourhood with the suburb of Toowong, but obtained independent suburb status on 16 November 1986. In January 2011, Auchenflower experienced flooding as part of the 2010–11 Queensland floods.
The Wesley Hospital is a private hospital located near the Auchenflower train station.